Genetiker

ARE YOU AN ENTHUSIASTIC SCIENTIST WITH EXPERTISE IN PROTEIN CRYSTALLOGRAPHY? WOULD YOU LIKE TO APPLY YOUR EXPERTISE AT A COMPANY THAT ARE FOLLOWING THE SCIENCE AND TURN IDEAS INTO LIFE CHANGING MEDICINES? THEN YOU MIGHT BE THE ONE WE ARE LOOKING FOR!   This is an opportunity for a collaborative, creative and hardworking lab-based protein structure scientist to play an influential role in drug discovery projects at AstraZeneca in Gothenburg, Sweden. The role is based in the Protein structure team within the Mechanistic & Structural Biology (M&SB) department based in Gothenburg, Sweden supporting biopharma drug discovery projects. In this position you will be a part of Discovery Sciences in AstraZeneca’s BioPharmaceuticals organization. The M&SB department has leading capabilities in mechanistic biology, compound profiling, biophysics, crystallography and cryo-EM. The Protein structure team has expertise in protein crystallography and is building a capability in cryo-electron microscopy. We have a highly automated lab for protein crystallography and cryo-EM sample preparation, and are constantly pushing the limits for what type of molecular targets can be subjected to structural studies, ranging from small single domain proteins to membrane proteins and large multi-protein complexes. The protein structure information is used to guide design of our lead molecules and to provide key mode of action information. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. WHAT YOU WILL DO: WORKING COLLABORATIVELY IN DRUG DISCOVERY PROJECTS ALONGSIDE MECHANISTIC AND STRUCTURAL BIOLOGISTS, PROTEIN SCIENTISTS, BIOPHARMA BIOSCIENTISTS AND CHEMISTS WITH RESPONSIBILITY FOR THE PROTEIN STRUCTURE ASPECT WITHIN A DRUG DISCOVERY PROJECT. THE ROLE ALSO INCLUDES YOU TO DEVELOP CRYSTAL SYSTEMS ENABLING ITERATIVE STRUCTURE BASED DRUG DESIGN PROGRAMS, FRAGMENT BASED LEAD DISCOVERY AND MODE OF ACTION STUDIES. YOU WILL SUPPORT MULTIPLE CRYSTALLIZATION PROJECTS IN PARRELLEL, WORK CLOSELY WITH OTHER CRYSTALLOGRAPHERS AS PART OF A DYNAMIC TEAM ENVIROMENT. OTHER RESPONSILITIES: • PERFORM CRYSTALLIZATION SCREENING OF PROTEINS, PROTEIN LIGANDS COMPLEXES, BIOLOGICAL MACROMOLECULES AND BIOLOGICAL MACROMOLECULE COMPLEXES. • COLLECT X-RAY DATA USING A NUMBER OF SYNCHROTRON BEAMLINES. • SUPPORT ’IN CRYSTAL’ FRAGMENT SCREENS, HTS READ OUT, AND OTHER HIT FINDING STRATEGIES. • IDENTIFY IMPROVEMENTS AND INNOVATIONS IN CRYSTALLIZATION TECHNIQUES. • WORK AS A TEAM PLAYER TO ENSURE DELIVERY OF QUALITY LEADS FOR PROJECTS. ESSENTIAL IN THE ROLE: • PH.D. IN BIOCHEMISTRY, MOLECULAR BIOLOGY OR A RELATED DISCIPLINE OR A BSC/MSC DEGREE WITH SIGNIFICANT PROVEN EXPERIENCE, PREFERABLY IN THE PHARMACEUTICAL OR BIOTECHNOLOGY INDUSTRY. • EXPERTISE IN PROTEIN CRYSTALLISATION AND X-RAY DATA COLLECTION. • SIGNIFICANT EXPERIENCE IN PROTEIN CHARACTERISATION. • INDEPENDENT ANALYSIS AND EVALUATION OF COMPLEX DATA AND DELIVERY OF DATA TO AGREED TIMELINES. THE SUCCESSFUL CANDIDATE SHOULD ALSO ENJOY TO COLLABORATE AND COMMUNICATE WITH ALL. AS WELL AS HAVE THE ABILITY TO OPERATE EFFECTIVELY IN A MULTI-DISCIPLINARY RESEARCH ENVIRONMENT AND TEAM. DESIRABLE IN THE ROLE: • EXPERIENCE IN PROTEIN STRUCTURE REFINEMENT AND INTERPRETATION. • EXPERIENCE IN RELATED AREAS, SUCH AS PROTEIN SCIENCE AND BIOPHYSICS. • EXPERIENCE WITH OTHER TECHNIQUES FOR STRUCTURAL STUDIES (CRYO-EM, SAXS). WHY ASTRAZENECA IN GOTHENBURG? With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. We nurture this collaboration and openness, by creating a site that has space for meetings, socialising and relaxation – where spontaneous moments can spark innovation. ABOUT ALTEN EVERY EMPLOYEE IS EQUALLY VALUABLE IN THE SUCCESS OF ALTEN! WE ARE DRIVEN BY MAKING PEOPLE GROW AND DEVELOP, WHICH IS WHY WE OFFER YOU THE OPPORTUNITY TO WORK WITH WHAT YOU ARE TRULY PASSIONATE ABOUT. AT ALTEN, WE HAVE A BROAD RANGE OF ASSIGNMENTS AT MOST OF THE LEADING COMPANIES IN SWEDEN IN SEVERAL DIFFERENT SECTORS, TO MAKE IT POSSIBLE FOR YOUR WISHES TO COME TRUE. WE OFFER BOTH NATIONAL AND INTERNATIONAL OPPORTUNITIES AND TOGETHER WITH YOUR COACHING MANAGER, YOU BUILD YOUR CAREER PATH SO YOU CONSTANTLY ARE ABLE TO DEVELOP AND ACHIEVE YOUR GOALS AND DREAMS! AS A CONSULTANT AT ALTEN, YOU WILL GET THE GENUINE TEAM FEELING AT YOUR ASSIGNMENT BUT ALSO A WONDERFUL TOGETHERNESS AT ALTEN. THROUGH OUR DIFFERENT INTERNAL NETWORKS, SUCH AS ALTEN SPORTS, [email protected] AND ALTEN INNOVATION YOU WILL GET THE OPPORTUNITY TO DRIVE TOPICS AND ACTIVITIES THAT ARE CLOSE TO YOUR HEART, TOGETHER WITH YOUR COLLEAGUES. ALL ACTIVITIES ARE OF COURSE OPTIONAL. WORK LIFE BALANCE IS OUR TOP PRIORITY. WE ALSO HAVE A COLLECTIVE AGREEMENT AND OTHER BENEFITS LIKE PENSION, INSURANCES AND WELLNESS GRANTS. WE BELIEVE IN GROWING TOGETHER!

We are curious, creative, and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Join AstraZeneca and apply your expertise in a company that are following the science and turn ideas into life changing medicines. We have an exciting opportunity for a talented Scientist to be based in Gothenburg, Sweden. Drug Product Delivery (DPD) within Pharmaceutical Technology & Development is the sole internal AstraZeneca department that packs, labels and distributes investigational medicinal products to clinical trial patients. We support launched, pre-launched and products under development within all our therapeutic areas. We work in a fast paced environment where flexibility and agility enable us to deliver high value to early phase clinical trials. The Scientist role will be a flexible role within Drug Product Deliveries three operational skill areas. Material Management, Pack Label and Distribution. We work in a environment where flexibility and agility enable us to deliver high value to early phase clinical trials. To complement our existing team, candidates with the following experiences is of interest: - Logistic experience from a complex supply chain organization - Knowledge / expertise in working with automated/semi-automated equipment in an operational environment - Drug Product Knowledge including management of Item/article and lot/batch management to ensure traceability on items/articles in a patient kit including a drug product, packaging material and patient labels from the pharmaceutical industry MAIN DUTIES AND RESPONSIBILITIES THE ROLE HOLDER WILL CONTRIBUTE TO THE DPD ORGANIZATION APPLYING THEIR EXPERTISE IN THE COMPLEX AND REGULATED GMP ENVIRONMENT. THE WORK IS FOCUSED ON BEING A FLEXIBLE OPERATIONAL SCIENTIST WITHIN AT LEAST TWO SKILLS. AS A SCIENTIST YOU WILL PERFORM AND DOCUMENT ALL THE OPERATIONAL WORK ACCORDING TO WRITTEN PROCEDURES AND GMPS WITH MANUAL AND/OR AUTOMATED SYSTEMS/EQUIPMENT. BE ENGAGED IN THE DEVELOPMENT AND IMPROVEMENT OF INTERNAL PROCESSES AND MANAGE DEVIATIONS. BE RESPONSIBLE FOR WRITING OF GMP AND SHE PROCEDURES WITHIN OWN SKILL AREAS AND WILL BE RESPONSIBLE FOR RELATED TRAINING AND COMPLIANCE ACTIVITIES. AS REQUIRED MAINTAIN DEFINED FACILITIES OR EQUIPMENT ACCORDING TO GMP STANDARDS AND BE PROACTIVE TO CONTRIBUTE TO PROJECTS/ACTIVITIES THROUGH APPLYING SPECIALIST KNOWLEDGE WITHIN APPROPRIATE AREAS. ESSENTIAL REQUIREMENTS AND SKILLS - BSC/MSC IN CHEMISTRY/PHARMACY/ENGINEERING OR EQUIVALENT EXPERIENCE. PREFERABLY 2 YEARS’ EXPERIENCE WITHIN PHARMACEUTICAL DEVELOPMENT - MANUFACTURING EXPERIENCE - DEMONSTRATED ABILITY TO WORK WITH TEAMS IN A CULTURALLY DIVERSE, COMPLEX AND CHANGING ENVIRONMENT MOST INTERNALLY BUT TO SOME EXTENT EXTERNALLY - CURIOUS AND INNOVATIVE MINDSET WITH PROBLEM SOLVING ABILITY - RESOLVE ISSUES WITH MINIMAL GUIDANCE -  GOOD WRITTEN AND VERBAL ENGLISH COMMUNICATION AND UNDERSTANDING BENEFICIAL REQUIREMENTS AND SKILLS - Great Understanding of principles, applications and management of SHE and GMP in an R&D environment - Understanding the disciplines in Drug Product Delivery, Supply Chain and Pharmaceutical development in order to contribute to an effective Supply Chain organization   ABOUT ALTEN EVERY EMPLOYEE IS EQUALLY VALUABLE IN THE SUCCESS OF ALTEN! WE ARE DRIVEN BY MAKING PEOPLE GROW AND DEVELOP, WHICH IS WHY WE OFFER YOU THE OPPORTUNITY TO WORK WITH WHAT YOU ARE TRULY PASSIONATE ABOUT. AT ALTEN, WE HAVE A BROAD RANGE OF ASSIGNMENTS AT MOST OF THE LEADING COMPANIES IN SWEDEN IN SEVERAL DIFFERENT SECTORS, TO MAKE IT POSSIBLE FOR YOUR WISHES TO COME TRUE. WE OFFER BOTH NATIONAL AND INTERNATIONAL OPPORTUNITIES AND TOGETHER WITH YOUR COACHING MANAGER, YOU BUILD YOUR CAREER PATH SO YOU CONSTANTLY ARE ABLE TO DEVELOP AND ACHIEVE YOUR GOALS AND DREAMS! AS A CONSULTANT AT ALTEN, YOU WILL GET THE GENUINE TEAM FEELING AT YOUR ASSIGNMENT BUT ALSO A WONDERFUL TOGETHERNESS AT ALTEN. THROUGH OUR DIFFERENT INTERNAL NETWORKS, SUCH AS ALTEN SPORTS, [email protected] AND ALTEN INNOVATION YOU WILL GET THE OPPORTUNITY TO DRIVE TOPICS AND ACTIVITIES THAT ARE CLOSE TO YOUR HEART, TOGETHER WITH YOUR COLLEAGUES. ALL ACTIVITIES ARE OF COURSE OPTIONAL. WORK LIFE BALANCE IS OUR TOP PRIORITY. WE ALSO HAVE A COLLECTIVE AGREEMENT AND OTHER BENEFITS LIKE PENSION, INSURANCES AND WELLNESS GRANTS. WE BELIEVE IN GROWING TOGETHER!